🚨 A HANDWRITTEN NOTE HAS BECOME THE KEY FOCUS IN A HEARTBREAKING FAMILY TRAGEDY 💔

The grandma found ᴅᴇᴀᴅ alongside her daughter and four grandchildren in her upstate New York home appears to have poisoned them all, police said in a shocking update Thursday — as the slain kids’ father spoke of his heartbreak at never seeing them again.

A handwritten note found at Amy Steadman’s home “strongly suggests” that she was “involved” in the deaths of her daughter, Sarah Myers, 44, and Myers’ four children: Harper Harmon, 13, Hudson Harmon, 11, and 10-year-old twins Gavin and Gracelynn, Mechanicville Chief of Police Bill Rabbitt told a press conference.

One of the children was stabbed, while the rest appear to have been poisoned — possibly in a rage over their dad recently getting custody, sources told Channel 13.

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“There is recovered evidence from inside the apartment indicating intentional poisoning — to include numerous prescriptions and over-the-counter medications,” Rabbit told reporters, noting no evidence of anyone else being involved.

“Evidence recovered during the investigation, including a handwritten note, and other circumstantial evidence, strongly suggests that Amy Steadman was involved in the deaths,” he said, stressing that the investigation is ongoing.

Sources told Channel 13 that the children were injected with drugs, with syringes found inside their grandma’s home.